An international team of researchers has discovered that protein HMGB1 is a critical component of the pathogenesis of malignant mesothelioma, one of the most dangerous forms of cancer, is closely related to exposure to asbestos and eriositis on the body.
As demonstrated by the new work of scientists led by experts from the University of Hawaii, a protein HMGB1 plays a crucial role in the development of malignant mesothelioma. The study examines in detail the process that causes the growth of mesothelioma, and gives scientists the opportunity to develop targeted treatments for this disease. The results were published in the July issue of the journal Cancer Research.
Mesothelioma is an aggressive cancer that is usually diagnosed at later stages, and which is difficult to treat is served. Average survival after diagnosis is less than a year. About 5% of patients diagnosed with early stages of the disease, live 5-10 years or more. Opening of a new biomarker may be useful for earlier detection of disease, as well as to develop effective strategies to prevent and combat this type of cancer.
Center for Cancer Research at the University of Hawaii is a world leader in the study of mesothelioma. Center scientists involved in scientific work, which resulted in the discovery of the gene that causes mesothelioma (BAP1).
Mesothelioma associated with occupational and environmental exposure to asbestos. Eriositis – a natural mineral fiber that can cause the development of mesothelioma. In the U.S., about 3,000 diagnosed cases each year.